Analgesic Activity of Aqueous Extract of Spermacoce Hispida in Mice

Aim: To evaluate the analgesic activity of aqueous extract of S. hispida on thermal and chemical method induced pain in mice. Materials and methods: 48 Adult albino mice (Swiss strain) weighing 25-30 gm were selected. 24 animals were allocated to each experimental model, in each model there were 4 groups. The control group received vehicle (10 ml /kg, p.o), standard group aspirin (300 mg /kg, p.o) and test groups received dried aqueous extract of S. hispida (100 mg /kg, 200 mg /kg p.o. respectively) 1 hr prior to acute study. The drugs were administered orally one hour before placing the animal over the hot plate or one before injecting 0.6% acetic acid. Results: All the tested doses of S. hispida on acute administration significantly delayed the reaction time in hot-plate method and reduced number of writhing in chemical method. Conclusion: The present study has shown that S. hispida has analgesic activity in mice.